2003 - 2004流感季节由金黄色葡萄球菌引起的重症社区获得性肺炎
Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season.
作者信息
Hageman Jeffrey C, Uyeki Timothy M, Francis John S, Jernigan Daniel B, Wheeler J Gary, Bridges Carolyn B, Barenkamp Stephen J, Sievert Dawn M, Srinivasan Arjun, Doherty Meg C, McDougal Linda K, Killgore George E, Lopatin Uri A, Coffman Rebecca, MacDonald J Kathryn, McAllister Sigrid K, Fosheim Gregory E, Patel Jean B, McDonald L Clifford
机构信息
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
出版信息
Emerg Infect Dis. 2006 Jun;12(6):894-9. doi: 10.3201/eid1206.051141.
During the 2003-04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk factors for MRSA. Twelve (71%) had laboratory evidence of influenza virus infection. All but 1 patient, who died on arrival, were hospitalized. Death occurred in 5 (4 with MRSA). S. aureus isolates were available from 13 (76%) patients (11 MRSA). Toxin genes were detected in all isolates; 11 (85%) had only genes for Panton-Valentine leukocidin. All isolates had community-associated pulsed-field gel electrophoresis patterns; all MRSA isolates had the staphylococcal cassette chromosome mec type IVa. In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA.
在2003 - 2004年流感季节，9个州报告了17例金黄色葡萄球菌社区获得性肺炎（CAP）病例；其中15例（88%）与耐甲氧西林金黄色葡萄球菌（MRSA）相关。患者的中位年龄为21岁；5例（29%）有基础疾病，4例（24%）有MRSA的危险因素。12例（71%）有流感病毒感染的实验室证据。除1例入院时死亡的患者外，其他患者均住院治疗。5例患者死亡（4例为MRSA感染）。13例（76%）患者的金黄色葡萄球菌分离株可获得（11例为MRSA）。所有分离株均检测到毒素基因；11例（85%）仅有杀白细胞素基因。所有分离株均有社区相关性脉冲场凝胶电泳图谱；所有MRSA分离株均为葡萄球菌盒式染色体mec IVa型。在MRSA高流行社区，流感活动高发期重症CAP的经验性治疗应考虑MRSA。
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