Khaw Kay-Tee, Jakes Rupert, Bingham Sheila, Welch Ailsa, Luben Robert, Day Nicholas, Wareham Nicholas
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, UK.
Int J Epidemiol. 2006 Aug;35(4):1034-43. doi: 10.1093/ije/dyl079. Epub 2006 May 18.
The health benefits of physical activity are well established, but the overall amount of physical activity associated with cardiovascular and other health outcomes, and whether the relationships are similar in men and women and at different ages is still debated. This may be partly related to different methods for assessing physical activity. Most studies have focused on leisure time physical activity.
We examined the prospective relationship between usual physical activity, taking into account both leisure and work activity, using a simple, pragmatic, four-point rating scale validated against heart rate monitoring, and cardiovascular disease incidence and total mortality after an average 8 years follow-up in 22,191 community living men and women aged 45-79 years with no known cardiovascular disease or cancer at baseline.
The relative risks (95% confidence interval) for all-cause mortality (1,553 deaths) for men and women who were moderately inactive, moderately active, and active compared with those who were inactive were 0.83 (0.73-0.95), 0.68 (0.58-0.80), and 0.68 (0.57-0.81), respectively, after adjusting for age, sex, systolic blood pressure, blood cholesterol, cigarette smoking, alcohol intake, diabetes, body mass index, and social class. The relationships were also consistent for cardiovascular disease incidence (3,079 events), in subgroups stratified by age, sex, body mass index, smoking status and social class, and after excluding deaths in the first 2 years. The combined scale was more consistently associated with mortality than the individual work and leisure time components separately.
When both work and leisure time physical activity patterns are taken into account, using a simple, pragmatic, validated questionnaire feasible for use in clinical and public health practice, even very moderate levels of usual physical activity are associated with significantly reduced risk of mortality and cardiovascular disease in men and women in the general population and potential population attributable impact of 14% for inactive compared with active levels. These findings may encourage efforts to increase physical activity levels not only in leisure time but also in usual daily working life.
体育活动对健康有益已得到充分证实,但与心血管及其他健康结果相关的体育活动总量,以及这些关系在男性和女性、不同年龄段是否相似仍存在争议。这可能部分与评估体育活动的不同方法有关。大多数研究都集中在休闲时间的体育活动上。
我们采用一种简单、实用的四点评分量表,该量表经心率监测验证,研究了考虑休闲和工作活动的日常体育活动与心血管疾病发病率及总死亡率之间的前瞻性关系,对22191名年龄在45 - 79岁、基线时无已知心血管疾病或癌症的社区居民男性和女性进行了平均8年的随访。
在调整年龄、性别、收缩压、血胆固醇、吸烟、饮酒、糖尿病、体重指数和社会阶层后,与不活动者相比,中度不活动、中度活动和活跃的男性和女性全因死亡率(1553例死亡)的相对风险(95%置信区间)分别为0.83(0.73 - )、0.68(0.58 - 0.80)和0.68(0.57 - 0.81)。在按年龄、性别、体重指数、吸烟状况和社会阶层分层的亚组中,以及在排除前两年的死亡病例后,这些关系在心血管疾病发病率(3079例事件)方面也一致。综合量表与死亡率的关联比单独的工作和休闲时间成分更一致。
当同时考虑工作和休闲时间的体育活动模式时,使用一种简单、实用、经验证且适用于临床和公共卫生实践的问卷,即使是非常适度的日常体育活动水平,也与普通人群中男性和女性死亡率和心血管疾病风险的显著降低相关,与活跃水平相比,不活动水平的潜在人群归因影响为14%。这些发现可能会鼓励人们不仅在休闲时间,而且在日常工作生活中努力增加体育活动水平。