McCormick F P, Newton A A
J Gen Virol. 1975 Apr;27(1):25-33. doi: 10.1099/0022-1317-27-1-25.
Ifection of LS cells with HSV-1 resulted in an inhibition of spermidine and spermine synthesis from putrescine, possibly through inhibition of host cell protein synthesis. The rate of putrescine uptake increased soon after infection, and later, polyamines were lost from the cells. Inhibition of spermidine and spermine synthesis by methylglyoxal bis (amidinohydrazone) did not affect virus replication.
用单纯疱疹病毒1型（HSV - 1）感染LS细胞会抑制由腐胺合成亚精胺和精胺，这可能是通过抑制宿主细胞蛋白质合成实现的。感染后不久，腐胺摄取速率增加，随后细胞中的多胺流失。甲基乙二醛双（脒腙）对亚精胺和精胺合成的抑制并不影响病毒复制。
