结直肠锯齿状腺瘤的临床病理特征
Clinico-pathological aspects of colorectal serrated adenomas.
作者信息
Chandra Ashish, Sheikh Adnan A, Cerar Anton, Talbot Ian C
机构信息
Department of Pathology, St Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, United Kingdom.
出版信息
World J Gastroenterol. 2006 May 7;12(17):2770-2. doi: 10.3748/wjg.v12.i17.2770.
AIM
To study the association of colorectal serrated adenomas (SAs) with invasive carcinoma, local recurrence, synchronicity and metachronicity of lesions.
METHODS
A total of 4,536 polyps from 1,096 patients over an eight-year period (1987-1995) were retrospectively examined. Adenomas showing at least 50% of serrated architecture were called SAs by three reviewing pathologists.
RESULTS
Ninety-one (2%) of all polyps were called SAs, which were found in 46 patients. Invasive carcinomas were seen in 3 out of 46 (6.4%) patients, of whom one was a case of familial adenomatous polyposis (FAP). A male preponderance was noted and features of a mild degree of dysplasia were seen in majority (n=75, 83%) of serrated adenomas. Follow-up ranged 1-12 years with a mean time of 5.75 years. Recurrences of SAs were seen in 3 (6.4%) cases, synchronous SAs in 16 (34.8%) cases and metachronous SAs in 9 (19.6%) cases.
CONCLUSION
Invasive carcinoma arising in serrated adenoma is rare, accounting for 2 (4.3%) cases studied in this series.
目的
研究结直肠锯齿状腺瘤（SAs）与浸润性癌、局部复发、病变的同时性和异时性之间的关联。
方法
回顾性检查了1987年至1995年八年间1096例患者的4536枚息肉。三位病理科医师将锯齿状结构至少占50%的腺瘤称为SAs。
结果
所有息肉中有91枚（2%）被称为SAs，发现于46例患者。46例患者中有3例（6.4%）出现浸润性癌，其中1例为家族性腺瘤性息肉病（FAP）。观察到男性居多，大多数（n = 75，83%）锯齿状腺瘤有轻度发育异常特征。随访时间为1至12年，平均时间为5.75年。SAs复发3例（6.4%），同时性SAs 16例（34.8%），异时性SAs 9例（19.6%）。
结论
锯齿状腺瘤中发生的浸润性癌很罕见，在本系列研究的病例中占2例（4.3%）。
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