Yoshida K, Sugawara Y, Higuchi H
Pharmacopsychiatry. 2006 May;39(3):114. doi: 10.1055/s-2006-946609.
Recently, tricyclic antidepressants (TCAs) have been used mainly for treatment-resistant depression (TRD) because of their significant side effects . We report a patient whose prolonged depressive symptoms dramatically improved after the cessation of TCAs. TCAs may cause deterioration of depressive symptoms due to their neurotoxicity.