解偶联蛋白的生理调节

The physiological regulation of uncoupling proteins.

作者信息

Nicholls David G

机构信息

Buck Institute for Age Research, Mitochondrial Physiology, Novato, CA 94945, USA.

出版信息

Biochim Biophys Acta. 2006 May-Jun;1757(5-6):459-66. doi: 10.1016/j.bbabio.2006.02.005. Epub 2006 Mar 6.

DOI:10.1016/j.bbabio.2006.02.005

PMID:16725104

Abstract

Despite the enormous interest in the roles of novel uncoupling proteins, there is still great uncertainty as to their mechanism and regulation. The regulation of the architypal uncoupling protein 1 from brown adipose tissue was elucidated more than 20 years ago. This review suggests that a number of the approaches and criteria developed for the study of UCP1 could with profit be applied to current investigations of the novel UCPs.

摘要

尽管人们对新型解偶联蛋白的作用有着极大的兴趣，但关于它们的机制和调节仍存在很大的不确定性。褐色脂肪组织中典型解偶联蛋白1的调节在20多年前就已阐明。这篇综述表明，为研究UCP1而开发的许多方法和标准可以有益地应用于当前对新型解偶联蛋白的研究。