山羊在催产素诱导发情期间13,14-二氢-15-酮前列腺素F(2α)和孕酮的血浆浓度。

Plasma concentrations of 13, 14-dihydro-15-keto prostaglandin F(2alpha) and progesterone during oxytocin-induced oestrus in the goat.

作者信息

Cooke R G, Homeida A M

机构信息

Department of Veterinary Physiology and Pharmacology, University of Liverpool, Liverpool L69 3BX UK.

出版信息

Theriogenology. 1982 Oct;18(4):453-60. doi: 10.1016/0093-691x(82)90167-4.

DOI:10.1016/0093-691x(82)90167-4

PMID:16725767

Abstract

Fertile oestrus was induced in dairy goats by sub-cutaneous administration of 100 i.u. oxytocin per day between days 3-6 of the oestrous cycle. Peripheral plasma concentrations of 13, 14-dihydro-15-keto-prostaglandin F(2alpha) (PGFM), the major metabolite of prostaglandin (PG) F(2alpha), were elevated significantly (P<0.001), relative to controls, 30 minutes after oxytocin with peak values of between 300-800 pg ml(-1). Unlike control animals, plasma progesterone concentrations did not rise in the oxytocin-treated group after day 4. These results lend support to the hypothesis that the luteolytic effect of oxytocin in goats may be mediated via uterine PG production.

摘要

在发情周期的第3至6天，通过每天皮下注射100国际单位的催产素，诱导奶山羊进入可育发情期。相对于对照组，在注射催产素30分钟后，前列腺素（PG）F2α的主要代谢产物13, 14-二氢-15-酮-前列腺素F2α（PGFM）的外周血浆浓度显著升高（P<0.001），峰值在300 - 800 pg/ml之间。与对照动物不同，催产素处理组在第4天后血浆孕酮浓度没有升高。这些结果支持了催产素对山羊的溶黄体作用可能通过子宫产生PG来介导的假说。