氯喹对人甲型流感病毒复制的体外抑制作用
In vitro inhibition of human influenza A virus replication by chloroquine.
作者信息
Ooi Eng Eong, Chew Janet Seok Wei, Loh Jin Phang, Chua Robert C S
机构信息
Defence Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive, #09-01, 117510, Singapore.
出版信息
Virol J. 2006 May 29;3:39. doi: 10.1186/1743-422X-3-39.
Abstract
Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.
摘要
氯喹是一种具有著名抗疟作用的9-氨基喹啉。它具有可用于抑制病毒复制的生化特性。我们在此报告，氯喹能够在体外抑制甲型流感病毒复制，并且氯喹对甲型流感病毒H1N1和H3N2的半数抑制浓度低于急性疟疾治疗期间达到的血浆浓度。鉴于抗病毒药物在流感大流行防范中发挥着至关重要的作用，氯喹添加到有限的抗流感药物范围中的潜力应进一步探索。
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