来自小叶香茶菜的具有抗增殖作用的对映-贝壳杉烷类化合物。

Antiproliferative ent-Kauranoids from Isodon parvifolius.

作者信息

Li Li-Mei, Li Guo-You, Huang Sheng-Xiong, Xiao Wei-Lie, Liao Xun, Lou Li-Guang, Ding Li-Sheng, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.

出版信息

Planta Med. 2006 Jun;72(8):740-5. doi: 10.1055/s-2006-931608. Epub 2006 May 29.

DOI:10.1055/s-2006-931608

PMID:16732517

Abstract

Nine new 7alpha,20-epoxy- ENT-kaurane diterpenoids, parvifolines O - W (1 - 9), together with five known analogues, lasiocarpanin (10), rosthorin A (11), longikaurin E (12), adenolin D (13) and longikaurin B (14), were isolated from the leaves of Isodon parvifolius. Their structures were determined by means of spectroscopic analysis. Selected diterpenoids (1 - 10) were tested for their antiproliferative activity against A549, HT-29 and K562 cells. Compounds 3, 7, 8 and 10 showed moderate inhibitory activity against all three cell lines.

摘要

从小叶香茶菜的叶子中分离出9个新的7α,20-环氧-对映-贝壳杉烷二萜类化合物，即小叶香茶素O - W（1 - 9），以及5个已知类似物，即毛果香茶素（10）、香茶菜素A（11）、长叶香茶素E（12）、腺花香茶素D（13）和长叶香茶素B（14）。通过光谱分析确定了它们的结构。对所选二萜类化合物（1 - 10）针对A549、HT - 29和K562细胞的抗增殖活性进行了测试。化合物3、7、8和10对所有三种细胞系均表现出中等抑制活性。