测量商业猪群中的连锁不平衡程度。

Measuring the extent of linkage disequilibrium in commercial pig populations.

作者信息

Harmegnies N, Farnir F, Davin F, Buys N, Georges M, Coppieters W

机构信息

Unit of Animal Genomics, Faculty of Veterinary Medicine, University of Liège (B43), 20 Bd de Colonster, 4000-Liège, Belgium.

出版信息

Anim Genet. 2006 Jun;37(3):225-31. doi: 10.1111/j.1365-2052.2006.01438.x.

DOI:10.1111/j.1365-2052.2006.01438.x

PMID:16734681

Abstract

To evaluate the extent of linkage disequilibrium in domestic pigs, we genotyped 33 and 44 unrelated individuals from two commercial populations for 29 and five microsatellite markers located on chromosomes 15 and 2 respectively. A high proportion of marker pairs up to 40 cM apart exhibited significant linkage disequilibrium in both populations. Pair-wise r(2) values averaged between 0.15 and 0.50 (depending on chromosome and population) for markers <1 cM apart and declined to values of 0.05 for more distant syntenic markers. Our results suggest that both populations underwent a bottleneck approximately 20 generations ago, which reduced the effective population size from thousands to <200 animals.

摘要

为了评估家猪的连锁不平衡程度，我们对来自两个商业群体的33头和44头无亲缘关系的个体进行了基因分型，分别针对位于第15号和第2号染色体上的29个和5个微卫星标记。在两个群体中，相距达40厘摩的标记对中有很大比例表现出显著的连锁不平衡。对于相距小于1厘摩的标记，成对的r(2)值平均在0.15至0.50之间（取决于染色体和群体），而对于更远的同线标记，该值下降至0.05。我们的结果表明，这两个群体大约在20代以前都经历了瓶颈效应，有效群体大小从数千只减少到了不到200只动物。