针对与内源性鼠C型白血病病毒相关抗原的细胞介导免疫
Cell-mediated immunity to antigens associated with endogenous murine C-type leukemia viruses.
作者信息
Hirsch M E, Kelly A P, Proffitt M R, Black P H
出版信息
Science. 1975 Mar 14;187(4180):959-61. doi: 10.1126/science.167435.
PMID:167435
Abstract
Splenic lymphocytes from (BALB/c times A/J) F 1 mice are cytotoxic for BALB/c fibroblasts infected with an endogenous C-type leukemia virus, but are not cytotoxic for uninfected BALB/c fibroblasts. These results indicate that mice do not exhibit cell-mediated immune tolerance to antigens associated with endogenous C-type viruses.
摘要
（BALB/c×A/J）F1代小鼠的脾淋巴细胞对感染内源性C型白血病病毒的BALB/c成纤维细胞具有细胞毒性，但对未感染的BALB/c成纤维细胞没有细胞毒性。这些结果表明，小鼠对内源性C型病毒相关抗原不表现出细胞介导的免疫耐受。
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