猫体内的类固醇代谢。[4-C]睾酮代谢产物的胆汁和尿液排泄。
Steroid metabolism in the cat. Biliary and urinary excretion of metabolites of [4-C]testosterone.
作者信息
Archer S E, Scratcherd T, Taylor W
机构信息
Department of Physiology, The Medical School, University of Newcastle upon Tyne.
出版信息
Biochem J. 1965 Mar;94(3):778-82. doi: 10.1042/bj0940778.
Abstract
- [4-(14)C]Testosterone was administered intravenously to anaesthetized male cats as a single injection or as a 45-60min. infusion. 2. Most of the administered radioactivity was excreted in the bile (70-80%); only 2.9-5.5% of the dose was excreted in the urine. 3. Bile and urine samples were hydrolysed successively to yield glucuronide, ;cold-acid-hydrolysed' and ;hot-acid-hydrolysed' fractions. 4. The proportion of glucuronides in bile decreased in successive samples, but cold-and hot-acid-hydrolysed metabolites showed no consistent change. 5. After hydrolysis most of the radioactivity in both bile and urine could not be extracted by ether from neutral aqueous solution.
摘要
- 将[4-(14)C]睾酮以单次注射或45 - 60分钟输注的方式静脉注射给麻醉的雄性猫。2. 大部分注入的放射性物质经胆汁排泄（70 - 80%）；仅2.9 - 5.5%的剂量经尿液排泄。3. 胆汁和尿液样本依次水解，得到葡糖醛酸化物、“冷酸水解”和“热酸水解”部分。4. 胆汁中葡糖醛酸化物的比例在连续样本中下降，但冷酸和热酸水解代谢物未显示出一致变化。5. 水解后，胆汁和尿液中的大部分放射性物质不能从中性水溶液中用乙醚提取。
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引用本文的文献
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