Todorovic M, Fischer M, Cremers F, Thom E, Schmidt R
Department of Radiotherapy and Radio-Oncology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Med Phys. 2006 May;33(5):1321-8. doi: 10.1118/1.2188077.
The capability of the new GafChromic EBT prototype B for external beam dose verification is investigated in this paper. First the general characteristics of this film (dose response, postirradiation coloration, influence of calibration field size) were derived using a flat-bed scanner. In the dose range from 0.1 to 8 Gy, the sensitivity of the EBT prototype B film is ten times higher than the response of the GafChromic HS, which so far was the GafChromic film with the highest sensitivity. Compared with the Kodak EDR2 film, the response of the EBT is higher by a factor of 3 in the dose range from 0.1 to 8 Gy. The GafChromic EBT almost does not show a temporal growth of the optical density and there is no influence of the chosen calibration field size on the dose response curve obtained from this data. A MatLab program was written to evaluate the two-dimensional dose distributions from treatment planning systems and GafChromic EBT film measurements. Verification of external beam therapy (SRT, IMRT) using the above-mentioned approach resulted in very small differences between the planned and the applied dose. The GafChromic EBT prototype B together with the flat-bed scanner and MatLab is a successful approach for making the advantages of the GafChromic films applicable for verification of external beam therapy.
本文研究了新型GafChromic EBT原型B用于外照射剂量验证的能力。首先,使用平板扫描仪得出该胶片的一般特性(剂量响应、辐照后着色、校准野大小的影响)。在0.1至8 Gy的剂量范围内,EBT原型B胶片的灵敏度比GafChromic HS高十倍,而GafChromic HS是迄今为止灵敏度最高的GafChromic胶片。在0.1至8 Gy的剂量范围内,与柯达EDR2胶片相比,EBT的响应高3倍。GafChromic EBT几乎未显示出光密度的时间增长,并且所选校准野大小对从该数据获得的剂量响应曲线没有影响。编写了一个MatLab程序来评估治疗计划系统和GafChromic EBT胶片测量的二维剂量分布。使用上述方法对外照射治疗(立体定向放射治疗、调强放射治疗)进行验证,结果显示计划剂量与实际应用剂量之间的差异非常小。GafChromic EBT原型B与平板扫描仪和MatLab一起,是使GafChromic胶片的优势适用于外照射治疗验证的成功方法。