L-核苷对映体作为抗病毒药物：一篇综述
L-nucleoside enantiomers as antivirals drugs: a mini-review.
作者信息
Mathé Christophe, Gosselin Gilles
机构信息
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS, Université Montpellier II, Case Courrier 008, Place Eugène Bataillon, 34095 Montpellier, France.
出版信息
Antiviral Res. 2006 Sep;71(2-3):276-81. doi: 10.1016/j.antiviral.2006.04.017. Epub 2006 May 23.
The discovery that some nucleoside analogues endowed with the unnatural L-configuration can possess biological activities has been a significant breakthrough in antiviral chemotherapy. In this regard, lamivudine (3TC) was the first L-nucleoside enantiomer approved against HIV and HBV, and several other L-nucleosides are currently under clinical development as antiviral agents.
一些具有非天然L构型的核苷类似物具有生物活性这一发现，是抗病毒化疗领域的一项重大突破。在这方面，拉米夫定（3TC）是首个被批准用于抗HIV和HBV的L核苷对映体，目前还有其他几种L核苷正在作为抗病毒药物进行临床开发。
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