Patriarca Marisa T, Goldman Katy Z, Dos Santos José M, Petri Valéria, Simões Ricardo Santos, Soares José M, Simões Manuel J, Baracat Edmund C
Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil.
Eur J Obstet Gynecol Reprod Biol. 2007 Feb;130(2):202-5. doi: 10.1016/j.ejogrb.2006.05.024. Epub 2006 Jun 23.
To analyze the dermal collagen of 15 postmenopausal women who had being treated with systemic estrogen replacement before and after using topical a 0.01% estrogen treatment.
Fifteen patients were included in this clinical trial using the systemic estrogen therapy for at least 1 year (minimum and maximum lengths of therapy were 13 and 40 months, respectively). A facial punch was performed in the preauricular area for collecting samples before and after the 16 weeks of treatment. Blood samples were also collected for estradiol level determination. The morphometric determination of epithelial and dermal thickness as well as dermal collagen were measured using a suitable software. The paired Student's t-test was used for statistical analysis.
The epithelial and dermal thickness enhanced after the topic estrogen therapy (P<0.01). The amount of collagen significantly increased after 16 weeks of treatment (P<0.001). The estrogen levels did not significant increase after the topical therapy (P > or = 0.05).
Our data suggested that topical estrogen associated to systemic estrogen therapy seems to increase the expression of skin collagen amount, which may prove to be beneficial for the postmenopausal facial skin.
分析15名在使用局部0.01%雌激素治疗前后接受过全身雌激素替代治疗的绝经后女性的真皮胶原蛋白。
15名患者纳入本临床试验，她们接受全身雌激素治疗至少1年（治疗的最短和最长时间分别为13个月和40个月）。在治疗前及治疗16周后，在耳前区域进行面部打孔以采集样本。还采集血样用于测定雌二醇水平。使用合适的软件对上皮和真皮厚度以及真皮胶原蛋白进行形态计量学测定。采用配对t检验进行统计分析。
局部雌激素治疗后上皮和真皮厚度增加（P<0.01）。治疗16周后胶原蛋白量显著增加（P<0.001）。局部治疗后雌激素水平无显著升高（P≥0.05）。
我们的数据表明，与全身雌激素治疗相关的局部雌激素似乎会增加皮肤胶原蛋白的表达量，这可能对绝经后面部皮肤有益。
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