Macrolactin N，一种由枯草芽孢杆菌产生的新型肽脱甲酰基酶抑制剂。
Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis.
作者信息
Yoo Jung-Sung, Zheng Chang-Ji, Lee Sangku, Kwak Jin-Hwan, Kim Won-Gon
机构信息
Korea Research Institute of Bioscience and Biotechnology, PO Box 115, Yusong, Daejeon 305-600, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2006 Sep 15;16(18):4889-92. doi: 10.1016/j.bmcl.2006.06.058. Epub 2006 Jun 30.
PMID:16809037
Abstract
A new 24-membered ring lactone, macrolactin N, was isolated from a culture broth of Bacillus subtilis and its structure was established by various spectral analysis. Macrolactin N inhibited Staphylococcus aureus peptide deformylase with an IC50 value of 7.5 microM and also showed antibacterial activity against Escherichia coli and S. aureus.
摘要
从枯草芽孢杆菌的培养液中分离出一种新的24元环内酯——大环内酯N，并通过各种光谱分析确定了其结构。大环内酯N对金黄色葡萄球菌肽脱甲酰酶具有抑制作用，IC50值为7.5微摩尔，并且对大肠杆菌和金黄色葡萄球菌也显示出抗菌活性。
Zotero 插件