人类血小板表达突触标记物VGLUT1和VGLUT2，并在聚集后释放谷氨酸。
Human platelets express the synaptic markers VGLUT1 and 2 and release glutamate following aggregation.
作者信息
Tremolizzo L, DiFrancesco J C, Rodriguez-Menendez V, Sirtori E, Longoni M, Cassetti A, Bossi M, El Mestikawy S, Cavaletti G, Ferrarese C
机构信息
Department of Neuroscience and Biomedical Technologies, University of Milano-Bicocca, Italy.
出版信息
Neurosci Lett. 2006 Sep 1;404(3):262-5. doi: 10.1016/j.neulet.2006.06.015. Epub 2006 Jun 30.
Vesicular glutamate transporters (VGLUTs) are involved in storing glutamate for secretion at the level of glutamatergic axon terminals, and for this reason they have been extensively used as markers to identify glutamate-releasing cells. Platelets have been considered as a suitable model for studying glutamatergic dysfunction because they perform glutamate uptake and express both external transporters, and NMDA-like receptors. Here, we show that platelets express the pre-synaptic markers VGLUT1 and VGLUT2 and release glutamate following aggregation, implying a possible contributory role in the pathophysiology of stroke, migraine, and other excitotoxic disorders.
囊泡谷氨酸转运体（VGLUTs）参与在谷氨酸能轴突终末水平储存谷氨酸以供分泌，因此它们已被广泛用作识别谷氨酸释放细胞的标志物。血小板被认为是研究谷氨酸能功能障碍的合适模型，因为它们进行谷氨酸摄取并表达两种外向转运体以及N-甲基-D-天冬氨酸（NMDA）样受体。在此，我们表明血小板表达突触前标志物VGLUT1和VGLUT2，并在聚集后释放谷氨酸，这意味着其在中风、偏头痛和其他兴奋性毒性疾病的病理生理学中可能起作用。
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