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用于治疗充血性心力衰竭的柔性与非柔性二尖瓣环:修复的差异耐久性

Flexible versus nonflexible mitral valve rings for congestive heart failure: differential durability of repair.

作者信息

Spoor Martinus T, Geltz Amy, Bolling Steven F

机构信息

Section of Cardiac Surgery, University of Michigan, Ann Arbor, Michigan 48109-0348, USA.

出版信息

Circulation. 2006 Jul 4;114(1 Suppl):I67-71. doi: 10.1161/CIRCULATIONAHA.105.001453.

Abstract

BACKGROUND

Surgical intervention is playing an increasingly important therapeutic role in congestive heart failure (CHF) patients with ischemia and dilated cardiomyopathy. Their mitral regurgitation (MR) is a result of left ventricular (LV) geometrical distortion. The optimal type of ring for CHF patients with geometric ventricular-based MR is unknown. This study reviewed the results of flexible versus nonflexible complete mitral valve rings in CHF patients with geometric mitral regurgitation.

METHODS AND RESULTS

Using a prospectively maintained database, patients undergoing mitral valve reconstruction (MVR) with either a flexible or nonflexible complete ring were identified on the basis of preoperative ejection fraction (EF) < or = 30% and no primary mitral pathology. These 2 groups of CHF patients with severe geometric MR were then compared in terms of recurrent MR requiring reoperation. Between 1992 and 2004, 289 patients with EF < or = 30%, received an undersized complete mitral annuloplasty ring as their MVR procedure. Of these, 170 patients had a flexible complete ring. In follow-up, 16 "flexible" patients (9.4%) required a repeat procedure for significant recurrent geometric MR and CHF (10 replacements, 3 re-repairs, 3 transplants). The average time to reoperation was 2.4 years. In contrast, 119 patients with an EF < or = 30% received a MVR using an undersized nonflexible complete ring. Only 3 "non-flexible" patients required a repeat operation, MVR (1), and 2 patients required a transplant. The time to reoperation was 4.0 years. A significant difference in reoperation rates, for recurrent MR, between the 2 groups (P=0.012). There were no differences between groups, in terms of age, ring size used, preoperative EF, LV size, MR grade, or New York Heart Association class.

CONCLUSIONS

Patients with CHF having a flexible ring have a higher likelihood of developing recurrent MR requiring reoperation. The use of a nonflexible ring appears to significantly reduce the need for repeat surgical procedures. Further refinement and development of nonflexible ring systems, aimed at LV restoration, deserve ongoing investigation.

摘要

背景

手术干预在患有缺血性和扩张型心肌病的充血性心力衰竭(CHF)患者中发挥着越来越重要的治疗作用。他们的二尖瓣反流(MR)是左心室(LV)几何形状扭曲的结果。对于基于心室几何形状的MR的CHF患者,最佳的环类型尚不清楚。本研究回顾了在患有几何二尖瓣反流的CHF患者中使用柔性与非柔性完整二尖瓣环的结果。

方法与结果

利用前瞻性维护的数据库,根据术前射血分数(EF)≤30%且无原发性二尖瓣病变,确定接受柔性或非柔性完整环二尖瓣重建(MVR)的患者。然后比较这两组患有严重几何MR的CHF患者再次手术时复发性MR的情况。1992年至2004年期间,289例EF≤30%的患者接受了尺寸偏小的完整二尖瓣环成形术作为其MVR手术。其中,170例患者使用了柔性完整环。随访中,16例“柔性”患者(9.4%)因显著复发性几何MR和CHF需要再次手术(10例置换,3例再次修复,3例移植)。再次手术的平均时间为2.4年。相比之下,119例EF≤30%的患者使用尺寸偏小的非柔性完整环进行了MVR。只有3例“非柔性”患者需要再次手术,1例进行MVR,2例需要移植。再次手术的时间为4.0年。两组之间因复发性MR再次手术的发生率有显著差异(P=0.012)。在年龄、使用的环尺寸、术前EF、LV大小、MR分级或纽约心脏协会分级方面,两组之间没有差异。

结论

患有CHF且使用柔性环的患者发生需要再次手术的复发性MR的可能性更高。使用非柔性环似乎显著减少了再次手术的需求。旨在恢复LV的非柔性环系统的进一步改进和开发值得持续研究。

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