Xiong T, McEvoy K, Morton D G, Halligan S, Lilford R J
Department of Public Health and Epidemiology, Public Health Building, The University of Birmingham, Edgbaston, Birmingham B15 2TT.
Br J Radiol. 2006 Dec;79(948):948-61. doi: 10.1259/bjr/58438178. Epub 2006 Jul 5.
CT colonography (CTC) is increasingly used to detect colonic polyps and cancers, but its impact in practice is also influenced by frequent detection of extracolonic lesions. We have previously documented the frequency and nature of such lesions. The current study was performed to assess the clinical resources and costs associated with the investigation and treatment of extracolonic lesions. We reviewed the reports of 225 consecutive CTC examinations carried out on patients with symptoms of bowel cancer. 116 of the 225 were reported to have one or more extracolonic findings. All 116 patients with an abnormality were followed up for 12-24 months. 24 patients underwent further actions (outpatient attendance, investigations, or surgical procedures) as a result of previously undiagnosed lesions unrelated to bowel cancer. The costs of these further actions were derived from the NHS Reference Costs manual 2004. The total cost for further investigations and interventions was 34,329 pounds sterling and the mean cost over the sample of 225 patients was 153 pounds sterling--more than the cost of the CTC itself. The costs were mainly generated by surgical procedures. Resources consumed as a result of extracolonic findings approximately doubled the costs of diagnostic CTC. These costs, along with inconvenience, anxiety, morbidity and occasionally even mortality suffered by patients, must be offset by the good done to some of those with sub-clinical but potentially lethal diseases.
CT结肠成像(CTC)越来越多地用于检测结肠息肉和癌症,但其在实际应用中的影响也受到结肠外病变频繁检出的影响。我们之前已记录了此类病变的频率和性质。本研究旨在评估与结肠外病变的检查和治疗相关的临床资源及成本。我们回顾了对有肠癌症状患者进行的225例连续CTC检查报告。225例中有116例报告有一个或多个结肠外发现。所有116例有异常的患者均接受了12至24个月的随访。24例患者因先前未诊断出的与肠癌无关的病变而采取了进一步措施(门诊就诊、检查或外科手术)。这些进一步措施的成本来自2004年英国国家医疗服务体系(NHS)参考成本手册。进一步检查和干预的总成本为34,329英镑,225例患者样本的平均成本为153英镑——超过了CTC本身的成本。成本主要由外科手术产生。结肠外发现所消耗的资源使诊断性CTC的成本增加了约一倍。这些成本,连同患者所遭受的不便、焦虑、发病率甚至偶尔的死亡率,必须通过对一些患有亚临床但可能致命疾病的患者所带来的益处来抵消。