Kubota Yutaka
Department of Respiratory Medicine, National Hospital Organization, Maizuru Medical Center.
Nihon Kokyuki Gakkai Zasshi. 2006 Jun;44(6):453-7.
A 74-year-old man who had been treated for autoimmune hemolytic anemia was admitted to our hospital for dry cough and shortness of breath. Chest X-ray revealed multiple round opacities. The pathological examination of a percutaneous biopsy specimen revealed B-cell malignant lymphoma of the diffuse large-cell type. Gallium scintigraphy showed positive accumulation only in the lungs, and thus a diagnosis of primary pulmonary lymphoma was made. He received several courses of R-CHOP therapy and achieved partial remission. Primary pulmonary malignant lymphoma associated with autoimmune hemolytic anemia is extremely rare. Although the underlying mechanism remains to be clarified, it is likely that Epskin-Barr virus infection leads to the development of malignant lymphomas in some cases.
一名曾接受自身免疫性溶血性贫血治疗的74岁男性因干咳和呼吸急促入住我院。胸部X线显示多个圆形阴影。经皮活检标本的病理检查显示为弥漫大B细胞型恶性淋巴瘤。镓扫描显示仅肺部有阳性聚集,因此诊断为原发性肺淋巴瘤。他接受了几个疗程的R-CHOP治疗并取得部分缓解。与自身免疫性溶血性贫血相关的原发性肺恶性淋巴瘤极为罕见。尽管潜在机制仍有待阐明,但在某些情况下,爱泼斯坦-巴尔病毒感染可能导致恶性淋巴瘤的发生。