血清尿酸作为心血管疾病和肾脏疾病的危险因素：旧有争议重燃。
Serum uric acid as a risk factor for cardiovascular and renal disease: an old controversy revived.
作者信息
Viazzi Francesca, Leoncini Giovanna, Ratto Elena, Pontremoli Roberto
机构信息
Department of Internal Medicine, University of Genoa, Genoa, Italy.
出版信息
J Clin Hypertens (Greenwich). 2006 Jul;8(7):510-8. doi: 10.1111/j.1524-6175.2006.04755.x.
Abstract
Hyperuricemia is commonly associated with traditional risk factors such as abnormalities in glucose metabolism, dyslipidemia, and hypertension. Recent studies have revived the controversy over the role of serum uric acid as an independent prognostic factor for cardiovascular mortality. The authors review clinical and experimental evidence concerning the role of serum uric acid in the development of cardiovascular and renal damage. Results of trials suggesting that serum uric acid variations over time may have a prognostic impact are also discussed.
摘要
高尿酸血症通常与传统风险因素相关，如糖代谢异常、血脂异常和高血压。最近的研究再次引发了关于血清尿酸作为心血管死亡率独立预后因素作用的争议。作者回顾了有关血清尿酸在心血管和肾脏损害发生中作用的临床和实验证据。还讨论了提示血清尿酸随时间变化可能具有预后影响的试验结果。
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