6-取代的3-(吡啶-4-基)-1,2,4-三唑并[3,4-b][1,3,4]噻二唑的合成及药理性质
Synthesis and pharmacological properties of 6-substituted 3-(pyridine-4-yl)-1,2,4-triazole [3,4-b][1,3,4]thiadiazoles.
作者信息
Invidiata F P, Grimaudo S, Giammanco P, Giammanco L
机构信息
Istituto Farmacòchimico-Dell'Università di Palermo, Italy.
出版信息
Farmaco. 1991 Dec;46(12):1489-95.
PMID:1687973
Abstract
A number of new 6-substituted 3-(pyridine-4-yl) 1,2,4-triazole[3,4-b][1,3,4]thiadiazoles were synthesized and evaluated for their pharmacological activity. Some of them exhibited moderate MAO, antimalarial and in vitro antitumor activity.
摘要
合成了一系列新型的6-取代-3-(吡啶-4-基)-1,2,4-三唑并[3,4-b][1,3,4]噻二唑，并对其药理活性进行了评估。其中一些化合物表现出中等的单胺氧化酶、抗疟和体外抗肿瘤活性。
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