Pavelec Vaclav, Polenik Pavel
ENT Clinic, Charles University Hospital, ORL Klinika FN Plzen, E. Benese 13, 30101 Plzen, Czech Republic.
Laryngoscope. 2006 Aug;116(8):1512-6. doi: 10.1097/01.mlg.0000227958.81725.f4.
The aim of this study was to compare the effectiveness of the Er,Cr:YSGG (Waterlase) laser with KTP and CO2 lasers in laser assisted uvulopalatoplasty (LAUP) for treatment of snoring.
This is a prospective study of 63 patients who were treated for snoring by LAUP either with Er,Cr:YSGG (n = 21) or with KTP (n = 21) or CO2 lasers (n = 21). Histologic analysis was performed, and the effects of KTP and Waterlase on soft tissue were compared.
Patients were examined by an ENT surgeon and tested with polysomnography. Probands who suffered from obstructive sleep apnea or had an apnea-hypopnea index of 15 or greater were excluded from the study. The remaining patients were assigned to either Er,Cr:YSGG, KTP, or CO2 laser therapy. The three lasers were compared from a postoperative recovery point of view by immunohistochemical examination.
Pain medications were used on average for 4.1, 6.5, and 10.1 days, and the times to return to normal diet were on average 4.5, 6.8, and 8.6 days in the Er,Cr:YSGG, KTP, and CO2 groups, respectively. Two cases of bleeding were observed in the CO2 group. Foreign body sensation occurred in 14%, 19%, and 19% of subjects in the Er,Cr:YSGG, KTP, and CO2 groups, respectively. Velopharyngeal insufficiency was noticed in one KTP treated patient; however, it was transient. Snoring and apnea-hypopnea index was significantly reduced in all groups. Significantly larger coagulation of soft tissue was found in the KTP group than in the Waterlase group.
Patients treated with Waterlase recovered more quickly in comparison with patients in the KTP and CO2 groups, which was confirmed by immunohistochemical findings. The laser techniques did not differ in effectiveness.
本研究旨在比较铒铬:钇-钪-镓石榴石(水激光)激光与KTP激光及二氧化碳激光在激光辅助悬雍垂腭咽成形术(LAUP)治疗打鼾中的有效性。
这是一项对63例接受LAUP治疗打鼾患者的前瞻性研究,其中21例采用铒铬:钇-钪-镓石榴石(水激光)治疗,21例采用KTP激光治疗,21例采用二氧化碳激光治疗。进行了组织学分析,并比较了KTP激光和水激光对软组织的影响。
患者由耳鼻喉科医生检查并进行多导睡眠图测试。患有阻塞性睡眠呼吸暂停或呼吸暂停低通气指数为15或更高的先证者被排除在研究之外。其余患者被分配接受铒铬:钇-钪-镓石榴石(水激光)、KTP激光或二氧化碳激光治疗。通过免疫组织化学检查从术后恢复的角度对三种激光进行比较。
铒铬:钇-钪-镓石榴石(水激光)组、KTP激光组和二氧化碳激光组使用止痛药物的平均天数分别为4.1天、6.5天和10.1天,恢复正常饮食的平均时间分别为4.5天、6.8天和8.6天。二氧化碳激光组观察到2例出血。铒铬:钇-钪-镓石榴石(水激光)组、KTP激光组和二氧化碳激光组分别有14%、19%和19%的受试者出现异物感。1例接受KTP激光治疗的患者出现了短暂的腭咽闭合不全。所有组的打鼾和呼吸暂停低通气指数均显著降低。KTP激光组的软组织凝固明显大于水激光组。
免疫组织化学结果证实,与KTP激光组和二氧化碳激光组患者相比,接受水激光治疗的患者恢复更快。激光技术在有效性方面没有差异。