[感染多房棘球绦虫和旋毛虫的BALB/c小鼠免疫反应的变化]

[Changes in the immune response of BALB/c mice coinfected with Heligmosomoides polygyrus and Trichinella spiralis].

作者信息

Doligalska M, Rzepecka J, Moskwa B, Laskowska M

机构信息

Zakład Parazytologii, Instytut Zoologii, Uniwersytet Warszawski, 02-096 Warszawa, ul. Miecznikowa 1.

出版信息

Wiad Parazytol. 2001;47(4):735-9.

PMID:16886419

Abstract

The influence of Heligmosomoides polygyrus on infection with Trichinella spiralis was studied in BALB/c mice. Mice coinfected with T. spiralis and previously given H. polygyrus harboured both nematode species till day 34. The number of T. spiralis muscle larvae was greater in mice coinfected with H. polygyrus/T. spiralis or T. spiralis/H. polygyrus than after infection with T. spiralis alone. Infection with H. polygyrus did not enhance eosinophil and IL-5 levels induced by T. spiralis. Additionally, the production of IgG1 specific to L1 T. spiralis was inhibited by co-infection. Changes in the levels of IFN-gamma and IgG2a implicated a disturbance in Th2 cell activation during protective response and resulted in the greater number of T. spiralis muscle larvae in coinfected mice.

摘要

在BALB/c小鼠中研究了多枝单睾线虫对旋毛虫感染的影响。先前感染过多枝单睾线虫的小鼠与旋毛虫共同感染后，两种线虫均可在小鼠体内存活至第34天。与单独感染旋毛虫相比，同时感染多枝单睾线虫/旋毛虫或旋毛虫/多枝单睾线虫的小鼠体内旋毛虫肌幼虫数量更多。感染多枝单睾线虫并未增强旋毛虫诱导的嗜酸性粒细胞和IL-5水平。此外，共同感染会抑制针对旋毛虫L1的IgG1产生。IFN-γ和IgG2a水平的变化表明在保护性反应过程中Th2细胞激活受到干扰，这导致共同感染小鼠体内的旋毛虫肌幼虫数量更多。