垂体腺苷酸环化酶激活肽对海人酸诱导的大鼠视网膜神经毒性的神经保护作用。
Neuroprotective effect of PACAP against kainic acid-induced neurotoxicity in rat retina.
作者信息
Seki Tamotsu, Nakatani Masayoshi, Taki Chisato, Shinohara Yuko, Ozawa Motoki, Nishimura Shigeru, Ito Hiroyuki, Shioda Seiji
机构信息
Department of Ophthalmology, Kozawa Eye Hospital Eye Research Center, 2-2-11 Gokencho, Mito, Ibaraki 3100063, Japan.
出版信息
Ann N Y Acad Sci. 2006 Jul;1070:531-4. doi: 10.1196/annals.1317.074.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion cells in the retina died after KA injection in the control group and PACAP treatment significantly promoted cell survival. These findings strongly suggest that PACAP plays very important roles in preventing cell death in the retina.
垂体腺苷酸环化酶激活多肽（PACAP）以保护啮齿动物大脑中延迟性神经元细胞死亡而闻名。为了研究PACAP在视网膜中的神经保护作用，我们检测了PACAP对大鼠视网膜中 kainic 酸（KA）诱导的神经毒性的影响。在对照组中，KA 注射后视网膜中的许多神经节细胞死亡，而 PACAP 处理显著促进了细胞存活。这些发现强烈表明 PACAP 在预防视网膜细胞死亡中发挥着非常重要的作用。
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