载脂蛋白E亚型对大鼠星形胶质细胞中β-淀粉样蛋白诱导的基质金属蛋白酶-9的影响。
Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes.
作者信息
Guo Shuzhen, Wang Sophia, Kim Woo Jean, Lee Sun-Ryung, Frosch Matthew P, Bacskai Brian J, Greenberg Steven M, Lo Eng H
机构信息
Department of Neurology, Mass General Hospital, Charlestown, MA, USA.
出版信息
Brain Res. 2006 Sep 21;1111(1):222-6. doi: 10.1016/j.brainres.2006.06.041. Epub 2006 Aug 17.
Matrix metalloproteinase-9 (MMP-9) may play a role in the inflammatory glial response during Alzheimer's disease (AD). Astrocytes can degrade beta-amyloid (Abeta) and extracellular proteolysis via MMP-9 may be involved. Because Apolipoprotein E (APOE) genotype is an important factor for AD, we ask whether various apoE isoforms can influence Abeta-induced MMP-9 responses in primary rat astrocytes. Our data show that apoE4 significantly dampens Abeta-induced MMP-9 levels, possibly by downregulating the Rho-Rho kinase (ROCK) pathway. Reduction of astrocytic MMP-9 by apoE4 may affect Abeta clearance and promote Abeta deposition in AD.
基质金属蛋白酶-9（MMP-9）可能在阿尔茨海默病（AD）的炎症性胶质细胞反应中起作用。星形胶质细胞可以降解β-淀粉样蛋白（Aβ），并且通过MMP-9的细胞外蛋白水解可能参与其中。由于载脂蛋白E（APOE）基因型是AD的一个重要因素，我们探究各种载脂蛋白E亚型是否能影响原代大鼠星形胶质细胞中Aβ诱导的MMP-9反应。我们的数据表明，载脂蛋白E4可能通过下调Rho-Rho激酶（ROCK）途径，显著抑制Aβ诱导的MMP-9水平。载脂蛋白E4降低星形胶质细胞的MMP-9可能会影响Aβ清除，并促进AD中Aβ的沉积。
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