细菌视紫红质薄膜的手性二次谐波产生活性机制。

Mechanism of the chiral SHG activity of bacteriorhodopsin films.

作者信息

Wampler Ronald D, Zhou Mingkang, Thompson David H, Simpson Garth J

机构信息

Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47906, USA.

出版信息

J Am Chem Soc. 2006 Aug 30;128(34):10994-5. doi: 10.1021/ja062671o.

DOI:10.1021/ja062671o

PMID:16925395

Abstract

The nonlinear optical activity of bacteriorhodopsin (bR) Langmuir-Blodgett (LB) films were investigated computationally and experimentally. The second harmonic generation optical rotary dispersion (SHG-ORD) response was calculated directly from the known structure and orientation of the PSB retinal chromophore within bR with no adjustable parameters. The predicted results agree remarkably well in sign, magnitude, and trend with the experimental SHG-ORD measurements. The calculations indicated negligible chirality with the tensor for the PSB retinal chromophore, but significant chiral-specific activity for the thin film through a relatively simple orientational mechanism.

摘要

对细菌视紫红质（bR）朗缪尔-布洛杰特（LB）膜的非线性光学活性进行了计算和实验研究。利用bR内视黄醛发色团PSB的已知结构和取向，直接计算了二次谐波产生光学旋转色散（SHG-ORD）响应，无需调整参数。预测结果在符号、大小和趋势上与实验SHG-ORD测量结果非常吻合。计算表明，PSB视黄醛发色团的张量手性可忽略不计，但通过相对简单的取向机制，薄膜具有显著的手性特异性活性。