Cryptic and complex chromosomal rearrangements and the deletion of TP53 gene in a patient with leukemic mantle cell lymphoma.

作者信息

Zhang Lijun, Kern Williams F, Yu Zongxing, Mulvihill John J, Li Shibo

机构信息

Department of Pediatrics, The University of Oklahoma Health Sciences Center, 941 Stanton L. Young Blvd., BSEB 224, Oklahoma City, OK 73104, USA.

出版信息

Cancer Genet Cytogenet. 2006 Sep;169(2):169-73. doi: 10.1016/j.cancergencyto.2006.04.002.

DOI:10.1016/j.cancergencyto.2006.04.002

PMID:16938577

Abstract

We present a case of leukemic mantle cell lymphoma with cryptic and complex chromosomal rearrangements, including multiple-way translocations involving chromosomes 8q24, 14q11/q32, 17p13.3, 17p13.1, 21q22, and 21q22; a deletion of the long arm of chromosome 10 [del(10)(q24)]; and a deletion of the TP53 gene in addition to t(11;14). We speculate that this series of chromosomal changes may disrupt the IgH gene, activate the c-MYC oncogene, inactivate the p53 tumor suppressor gene, and disrupt other cancer-related genes either within or flanking the chromosomal breakpoints. This combinational effect causes the progression of mantle cell lymphoma.

摘要