与拉莫三嗪相关的局限性紫癜。

Localized purpura associated with lamotrigine.

作者信息

Amlie-Lefond Catherine M, Felgenhauer Judy L, Leong Alan D

机构信息

Department of Neurology, Division of Pediatric Neurology, Medical College of Wisconsin, Milwaukee, 53226, USA.

出版信息

Pediatr Neurol. 2006 Sep;35(3):227-8. doi: 10.1016/j.pediatrneurol.2006.02.015.

DOI:10.1016/j.pediatrneurol.2006.02.015

PMID:16939867

Abstract

Antiepileptic drug hypersensitivity syndrome consists of fever, rash, and internal organ involvement and usually occurs within the first 2 months of initiation of therapy. This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy. This case study is the second report of localized purpura after prolonged lamotrigine treatment suggesting this may be an atypical lamotrigine-induced drug reaction.

摘要

抗癫痫药物超敏反应综合征包括发热、皮疹和内脏器官受累，通常发生在治疗开始后的前2个月内。本报告描述了一名13岁女性，患有右额叶高级别胶质瘤和复杂部分性癫痫，在接受拉莫三嗪单药治疗23个月后出现局部紫癜。本病例研究是拉莫三嗪长期治疗后局部紫癜的第二篇报告，提示这可能是一种非典型的拉莫三嗪诱导的药物反应。