Ruokoranta Tanja M, Grahn A Marika, Ravantti Janne J, Poranen Minna M, Bamford Dennis H
Department of Biological and Environmental Sciences, Institute of Biotechnology, Viikki Biocenter 2, P.O. Box 56 (Viikinkaari 5), FIN-00014 University of Helsinki, Finland.
J Virol. 2006 Sep;80(18):9326-30. doi: 10.1128/JVI.01005-06.
Single-stranded RNA (ssRNA) bacteriophages of the family Leviviridae infect gram-negative bacteria. They are restricted to a single host genus. Phage PRR1 is an exception, having a broad host range due to the promiscuity of the receptor encoded by the IncP plasmid. Here we report the complete genome sequence of PRR1. Three proteins homologous with those of other ssRNA phages, i.e., maturation, coat, and replicase proteins, were identified. A fourth protein has a lysis function. Comparison of PRR1 with other members of the Leviviridae family places PRR1 in the genus Levivirus with some characteristics more similar to those of members of the genus Allolevivirus.
微小RNA病毒科的单链RNA（ssRNA）噬菌体感染革兰氏阴性菌。它们仅限于单一宿主属。噬菌体PRR1是个例外，由于IncP质粒编码的受体具有混杂性，它具有广泛的宿主范围。在此我们报告PRR1的完整基因组序列。鉴定出了三种与其他ssRNA噬菌体的蛋白质同源的蛋白质，即成熟蛋白、外壳蛋白和复制酶蛋白。第四种蛋白质具有裂解功能。将PRR1与微小RNA病毒科的其他成员进行比较后发现，PRR1属于轻小噬菌体属，其某些特征与奇异轻小噬菌体属成员的特征更为相似。
