Gorgey A S, Dudley G A
Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48108-0744, USA.
Spinal Cord. 2007 Apr;45(4):304-9. doi: 10.1038/sj.sc.3101968. Epub 2006 Aug 29.
Cross-sectional and longitudinal design.
(1) To quantify skeletal muscle cross-sectional area (CSA) after correcting for intramuscular fat (IMF) in thigh muscle groups 6 weeks after incomplete spinal cord injury (SCI), (2) to monitor the changes in muscle CSA and IMF after 3 months from the initial measurement.
Academic institution Athens, GA, USA.
Six incomplete SCI patients (28+/-4 years, 178+/-5 cm and 78+/-6 kg, mean+/-SE, C7 to L3, American Spinal Injury Association B or C) were tested at 5+/-1 weeks and 3 months after the initial measurement. T1-weighted magnetic resonance images were taken of both thighs. Six able-bodied (AB) controls were matched in age, sex, height and weight (29+/-4 years, four male and two female subjects, 179+/-5 cm and 77+/-6 kg).
At 6 weeks post-injury, muscle CSA was 82+/-4 cm(2) in incomplete SCI and 123+/-21 cm(2) in AB controls (P=0.04). IMF CSA was 5.2+/-1.3 and 2.3+/-0.6 cm(2) in incomplete SCI and AB controls, respectively (P=0.03). Relative IMF was three-fold higher (P=0.03) in the SCI group versus AB controls (5.8+/-1.4 versus 2.0+/-0.6%). After 3 months, IMF increased 26% in the SCI group compared to the initial measurement (P=0.02).
Skeletal muscle atrophy is associated with greater IMF accumulation in SCI group 6 weeks post-injury compared to AB controls. Moreover, IMF continues to increase over time in incomplete SCI.
横断面和纵向设计。
（1）在不完全性脊髓损伤（SCI）6周后，校正大腿肌群肌内脂肪（IMF）后量化骨骼肌横截面积（CSA）；（2）在初次测量3个月后监测肌肉CSA和IMF的变化。
美国佐治亚州雅典的学术机构。
6例不完全性SCI患者（年龄28±4岁，身高178±5cm，体重78±6kg，平均±标准误，损伤节段C7至L3，美国脊髓损伤协会分级为B或C级）在初次测量后5±1周和3个月时接受测试。对双侧大腿进行T1加权磁共振成像。选取6名年龄、性别、身高和体重相匹配的健全（AB）对照者（年龄29±4岁，4名男性和2名女性，身高179±5cm，体重77±6kg）。
损伤后6周，不完全性SCI患者的肌肉CSA为82±4cm²，AB对照者为123±21cm²（P=0.04）。不完全性SCI患者和AB对照者的IMF CSA分别为5.2±1.3cm²和2.3±0.6cm²（P=0.03）。SCI组的相对IMF是AB对照组的3倍（P=0.03）（分别为5.8±1.4%和2.0±0.6%）。3个月后，SCI组的IMF较初次测量时增加了26%（P=0.02）。
与AB对照者相比，SCI组在损伤后6周骨骼肌萎缩与更多的IMF蓄积有关。此外，不完全性SCI患者的IMF随时间持续增加。
