人工甜味混合饮料与常规混合饮料相比，会加快胃排空并增加酒精吸收。
Artificially sweetened versus regular mixers increase gastric emptying and alcohol absorption.
作者信息
Wu Keng-Liang, Chaikomin Reawika, Doran Selena, Jones Karen L, Horowitz Michael, Rayner Christopher K
机构信息
Department of Medicine, University of Adelaide, Royal Adelaide Hospital, South Australia, Australia.
出版信息
Am J Med. 2006 Sep;119(9):802-4. doi: 10.1016/j.amjmed.2006.02.005.
BACKGROUND
Mixed alcoholic drinks are increasingly being consumed in "diet" varieties, which could potentially empty more rapidly from the stomach and thereby increase the rate of alcohol absorption when compared with "regular" versions containing sugar.
METHODS
We studied 8 healthy males twice in randomized order. On each day, they consumed an orange-flavored vodka beverage (30 g ethanol in 600 mL), made with either "regular" mixer containing sucrose (total 478 kcal), or "diet" mixer (225 kcal).
RESULTS
Gastric half-emptying time measured by ultrasound (mean+/-standard deviation) was less for the "diet" than the "regular" drink (21.1+/-9.5 vs 36.3+/-15.3 minutes, P <.01). Both the peak blood ethanol concentration (0.053+/-0.006 vs 0.034+/-0.008 g%, P <.001) and the area under the blood ethanol concentration curve between 0 and 180 minutes (5.2+/-0.7 vs 3.2+/-0.7 units, P <.001) were greater with the "diet" drink.
CONCLUSIONS
Substitution of artificial sweeteners for sucrose in mixed alcoholic beverages may have a marked effect on the rate of gastric emptying and the blood alcohol response.
背景
含酒精的混合饮料越来越多地以“低热量”形式被饮用，与含糖的“常规”版本相比，其在胃中排空可能更快，从而增加酒精吸收速率。
方法
我们对8名健康男性进行了两次研究，采用随机顺序。每天，他们饮用一种橙汁味伏特加饮料（600毫升中含30克乙醇），该饮料用含蔗糖的“常规”混合剂制成（共478千卡），或用“低热量”混合剂制成（225千卡）。
结果
通过超声测量的胃半排空时间（平均值±标准差），“低热量”饮料比“常规”饮料短（21.1±9.5分钟对36.3±15.3分钟，P<.01）。“低热量”饮料的血乙醇浓度峰值（0.053±0.006对0.034±0.008克%，P<.001）和0至180分钟血乙醇浓度曲线下面积（5.2±0.7对3.2±0.7单位，P<.001）均更高。
结论
在含酒精混合饮料中用人工甜味剂替代蔗糖可能对胃排空速率和血酒精反应有显著影响。
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