Leccese Kathryn, Ferreira José, Delorme Jocelyn, Montreuil Bernard
Department of Surgery, Division of Vascular Surgery, Hôpital Maisonneuve-Rosemont.
J Vasc Surg. 2006 Sep;44(3):654-7. doi: 10.1016/j.jvs.2006.05.024.
An infected pseudoaneurysm of the right common femoral artery in a 69-year-old patient receiving methotrexate therapy was confirmed to have been caused by Mycobacterium tuberculosis. After surgical excision of the aneurysm and revascularization using femoral vein, cutaneous manifestations of M tuberculosis infection in the foot complicated the course. We hypothesized that methotrexate may have triggered the reactivation of dormant tuberculosis in this patient. Because extrapulmonary tuberculous pseudoaneurysms are clinically similar to other types of infected pseudoaneurysm, M tuberculosis infection should always be suspected during the initial diagnosis. We propose that mycobacterial cultures should be routine when initial cultures and Gram stain are negative.
一名69岁正在接受甲氨蝶呤治疗的患者,其右股总动脉感染性假性动脉瘤经确诊由结核分枝杆菌引起。在对动脉瘤进行手术切除并使用股静脉进行血管重建后,足部出现了结核分枝杆菌感染的皮肤表现,使病程复杂化。我们推测甲氨蝶呤可能触发了该患者潜伏结核的重新激活。由于肺外结核性假性动脉瘤在临床上与其他类型的感染性假性动脉瘤相似,因此在初步诊断时应始终怀疑结核分枝杆菌感染。我们建议,当初始培养和革兰氏染色均为阴性时,应常规进行分枝杆菌培养。