Boon Albert Eduard, de Boer Sjoukje Berdina Beike
Poortmolen 121, 2906 RN Capelle aan den IJssel, The Netherlands.
Eur Child Adolesc Psychiatry. 2007 Mar;16(2):79-86. doi: 10.1007/s00787-006-0576-x. Epub 2006 Sep 8.
To examine the stability of treatment outcome one year after discharge from an inpatient treatment programme for adolescents with severe behavioural problems combined with psychiatric disorders.
Symptom Check List-90 Revised (SCL-90 R) ratings were obtained at admission, discharge and one-year follow-up for 75 patients. Treatment outcome was determined by calculating clinically significant change on the SCL-90 R Global Severity Index (GSI) between admission and discharge. Stability of treatment outcome was determined by comparing the clinically significant changes on the GSI between admission and discharge, and between admission and follow-up.
Compared to baseline, 46.7% of the patients recovered (reliable change was found and their GSI at discharge was below the cutoff point for the functional population), 20% improved (reliable change was found, but the GSI was still above the cutoff point). For the other patients no reliable change was found (12.0%) or they deteriorated (21.3%). At follow-up, compared to the base score, 52.0% recovered, 13.3% improved, 12.0% showed no reliable change, and 22.7% deteriorated. Although for the whole sample no significant change was found between discharge and follow-up, some individual patients continued to improve after discharge, while others deteriorated. Analyses show that drug usage during the follow-up period is a strong predictor for these changes.
The results indicated that the majority of the patients recovered or improved during treatment and this treatment outcome was relatively stable at one-year follow-up. However, in a minority of patients the treatment results deteriorated during the one-year follow-up period. Drug usage turned out to be an important predictor for this deterioration.
研究患有严重行为问题并伴有精神障碍的青少年患者出院一年后治疗效果的稳定性。
对75例患者在入院、出院及一年随访时进行症状自评量表-90修订版(SCL-90 R)评分。通过计算入院与出院之间SCL-90 R全球严重程度指数(GSI)的临床显著变化来确定治疗效果。通过比较入院与出院之间以及入院与随访之间GSI的临床显著变化来确定治疗效果的稳定性。
与基线相比,46.7%的患者康复(发现有可靠变化且出院时GSI低于功能人群的临界值),20%的患者病情改善(发现有可靠变化,但GSI仍高于临界值)。其他患者未发现可靠变化(12.0%)或病情恶化(21.3%)。随访时,与基础评分相比,52.0%的患者康复,13.3%的患者病情改善,12.0%的患者未发现可靠变化,22.7%的患者病情恶化。虽然整个样本在出院和随访之间未发现显著变化,但一些个体患者出院后继续改善,而另一些患者则病情恶化。分析表明,随访期间的药物使用是这些变化的有力预测指标。
结果表明,大多数患者在治疗期间康复或病情改善,且这种治疗效果在一年随访时相对稳定。然而,少数患者在一年随访期间治疗效果恶化。药物使用被证明是这种恶化的一个重要预测指标。