Fein George, Di Sclafani Victoria, Finn Peter, Scheiner Diane L
Neurobehavioral Research, Inc., 201 Tamal Vista Boulevard, Corte Madera, CA 94925-1110, USA.
Drug Alcohol Depend. 2007 Mar 16;87(2-3):139-45. doi: 10.1016/j.drugalcdep.2006.08.009. Epub 2006 Sep 11.
Psychiatric comorbidity in alcohol use disorders is clearly established, however most studies ignore data on psychiatric symptom counts that do not meet criteria for a diagnosis. We examined psychiatric symptom counts and psychological measures in the domains of anxiety, mood and externalizing pathology in 48 long-term abstinent alcoholics (LTAA) compared to 48 age/gender comparable light/non-drinking controls (NC).
Continuous measures of pathology (i.e., symptoms counts and psychological assessments) in each domain were compared between groups for: (1) all study participants, (2) excluding individuals with a lifetime psychiatric diagnosis in the domain, and (3) excluding individuals with a current psychiatric diagnosis in the domain.
Psychiatric symptom counts and psychological pathology were greater in LTAA than NC. The differences between groups on these measures were not reduced by removal of individuals with lifetime or current diagnoses.
The bulk of the difference between LTAA and NC in psychiatric illness was carried by sub-diagnostic psychopathology. In comparison to the limited view provided by using only symptomatology that meets criteria for a diagnosis, the use of continuous measures of psychiatric symptomatology and psychological abnormality yields a much more accurate picture of psychiatric illness co-occurring with alcoholism.
酒精使用障碍中的精神疾病共病已得到明确证实,然而大多数研究忽略了不符合诊断标准的精神症状计数数据。我们对48名长期戒酒的酗酒者(LTAA)与48名年龄/性别匹配的轻度/不饮酒对照者(NC)的焦虑、情绪和外化病理领域的精神症状计数及心理测量指标进行了研究。
对每组人群在各领域的病理连续测量指标(即症状计数和心理评估)进行比较,具体包括:(1)所有研究参与者;(2)排除该领域有终生精神疾病诊断的个体;(3)排除该领域有当前精神疾病诊断的个体。
LTAA的精神症状计数和心理病理状况比NC更严重。去除有终生或当前诊断的个体后,两组在这些指标上的差异并未减小。
LTAA和NC在精神疾病方面的大部分差异是由亚诊断性精神病理造成的。与仅使用符合诊断标准的症状学所提供的有限观点相比,使用精神症状学和心理异常的连续测量能更准确地呈现与酒精中毒共发的精神疾病情况。