Castro Daniele P, Moraes Caroline S, Garcia Eloi S, Azambuja Patrícia
Departamento de Bioquímica e Biologia Molecular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Avenida Brasil 4354, Manguinhos, CEP 21045-900, Rio de Janeiro, RJ, Brazil.
Exp Parasitol. 2007 Feb;115(2):200-4. doi: 10.1016/j.exppara.2006.08.001. Epub 2006 Sep 20.
Studies were carried out on the effects of different carbohydrates on the lysis of Trypanosoma cruzi, Trypanosoma rangeli and erythocytes caused by the bacteria Serratia marcescens variants SM 365 and RPH. High concentrations of d-mannose were found to protect T. cruzi and T. rangeli markedly diminishing the lysis caused by S. marcescens. However, this carbohydrate is unable to interfere with the hemolysis induced by SM 365 and RPH variants. These results showed that the trypanolytic effect induced by S. marcescens SM 365 and RPH variants is dependent on d-mannose and distinct from the hemolytic activity, strongly suggesting that bacterial fimbriae are relevant to S. marcescens in lysis of parasites.
开展了关于不同碳水化合物对由粘质沙雷氏菌变种SM 365和RPH引起的克氏锥虫、兰氏锥虫及红细胞裂解作用的研究。发现高浓度的d-甘露糖可保护克氏锥虫和兰氏锥虫，显著减少由粘质沙雷氏菌引起的裂解。然而，这种碳水化合物无法干扰由SM 365和RPH变种诱导的溶血作用。这些结果表明，粘质沙雷氏菌SM 365和RPH变种诱导的锥虫溶解作用依赖于d-甘露糖，且与溶血活性不同，强烈提示细菌菌毛与粘质沙雷氏菌对寄生虫的裂解作用相关。
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