Avdić Dijana, Pecar Dzemal, Mujić-Skikić Emela, Pecar Ehlimana
Orthopaedic and Trauma Clinic, Clinical Centre University of Sarajevo, Bosnia and Herzegovina.
Bosn J Basic Med Sci. 2006 Aug;6(3):84-8. doi: 10.17305/bjbms.2006.3151.
Osteoarthritis (OA) is a group of overlapping disorders, which may have different aetiology but similar biological, morphologic and clinical outcome. In osteoarthritis, process will not encompass the joint cartilage only, but the entire joint, including sub-hondral bone, ligaments, capsule, and sinovial membrane and surrounding muscles. Osteoarthritis is a multi-factor disorder of sinovial joints, which occurs as result of mechanical and biological factors, which destabilise normal hondrocyte function, partitioning of cartilage, extra-cellular matrix and sub-hondral bone. The earliest changes, which are restricted to the joint cartilage surface only, do not cause any subjective feeling. The pain in arthrosis occurs (or re-occurs) a bit later, Diagnosis will be determined based on clinical exam as well as signs and symptoms present. Symptomatic and functional treatment of osteoarthritis as one of rheumatic disorders must be taken throughout years, sometimes throughout a lifetime. It encompasses application of many medications and physical therapy procedures.
骨关节炎(OA)是一组重叠性疾病,其病因可能不同,但生物学、形态学和临床结果相似。在骨关节炎中,病变过程不仅累及关节软骨,还包括整个关节,如软骨下骨、韧带、关节囊、滑膜及周围肌肉。骨关节炎是滑膜关节的多因素疾病,由机械和生物学因素导致,这些因素破坏了正常软骨细胞功能、软骨、细胞外基质和软骨下骨的结构。最早的变化仅局限于关节软骨表面,不会引起任何主观感觉。骨关节炎的疼痛稍后出现(或再次出现),诊断将基于临床检查以及所呈现的体征和症状来确定。作为风湿性疾病之一,骨关节炎的症状性和功能性治疗必须持续数年,有时甚至是终身。这包括使用多种药物和物理治疗方法。