N-甲基-D-天冬氨酸受体对于释放巩固的听觉恐惧记忆至关重要。
NMDA receptors are critical for unleashing consolidated auditory fear memories.
作者信息
Ben Mamou Cyrinne, Gamache Karine, Nader Karim
机构信息
Psychology Department, McGill University, 1205 Dr. Penfield Avenue, Montreal, Quebec H3A 1B1, Canada.
出版信息
Nat Neurosci. 2006 Oct;9(10):1237-9. doi: 10.1038/nn1778. Epub 2006 Sep 24.
Memories are dynamic and can change when recalled. The process that returns memories to a labile state during remembering is unclear. We found that the presence of NMDA, but not AMPA, receptor antagonists in the amygdala prior to recall prevented the consolidated fear memory from returning to a labile state. These findings suggest that NMDA receptors in the amygdala are critical for transforming a memory from a fixed to a labile state.
记忆是动态的，在被回忆时可能会发生变化。在回忆过程中使记忆恢复到不稳定状态的过程尚不清楚。我们发现，在回忆前杏仁核中存在NMDA受体拮抗剂而非AMPA受体拮抗剂，可阻止巩固的恐惧记忆恢复到不稳定状态。这些发现表明，杏仁核中的NMDA受体对于将记忆从固定状态转变为不稳定状态至关重要。
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