与单脱氧藤黄绿菌素相关的新型富溴吡咯衍生物的合成及抗菌活性
Synthesis and antimicrobial activity of new bromine-rich pyrrole derivatives related to monodeoxypyoluteorin.
作者信息
Raimondi Maria Valeria, Cascioferro Stella, Schillaci Domenico, Petruso Salvatore
机构信息
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, via Archirafi 32, 90123 Palermo, PA, Italy.
出版信息
Eur J Med Chem. 2006 Dec;41(12):1439-45. doi: 10.1016/j.ejmech.2006.07.009. Epub 2006 Sep 25.
PMID:17000033
Abstract
The synthesis and antimicrobial activity of new pyrrole derivatives structurally related to monodeoxypyoluteorin are described. The insertion of a keto or methylene spacer between the phenol group and the pyrroloyl moiety of brominated 2-(2'-hydroxybenzoyl)pyrroles leads to a decrease of the antibacterial activity.
摘要
描述了与单脱氧绿胶霉素结构相关的新型吡咯衍生物的合成及其抗菌活性。在溴化2-(2'-羟基苯甲酰基)吡咯的酚基和吡咯酰部分之间插入一个酮基或亚甲基间隔基会导致抗菌活性降低。
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