van den Hazel Peter, Zuurbier Moniek, Babisch Wolfgang, Bartonova Alena, Bistrup Marie Louise, Bolte Gabriele, Busby Chris, Butter Maureen, Ceccatelli Sandra, Fucic Aleksandra, Hanke Wojtec, Johansson Carolina, Kohlhuber Martina, Leijs Marike, Lundqvist Christofer, Moshammer Hanns, Naginiene Rima, Preece Alan, Ronchetti Roberto, Salines Georges, Saunders Margaret, Schoeters Greet, Stilianakis Nikolaos, ten Tusscher Gavin, Koppe Janna G
Public Health Services Gelderland Midden, Arnhem, The Netherlands.
Acta Paediatr Suppl. 2006 Oct;95(453):18-25. doi: 10.1080/08035320600885846.
Facts and hypotheses on the relationship between some children's diseases or disorders and external stressors during the developmental stage of a child, both prenatally and postnatally are described in literature. In this paper the following changes in patterns and causes of the main childhood illnesses are summarized and recommendations for actions are made. Prematurity. Intra-uterine growth restriction. Testicular dysgenesis syndrome. Type I and Type II diabetes. Asthma, atopy and hay fever. Autism. Attention deficit hyperactivity disorder (ADHD). Learning disabilities. Cancer. Obesity. Hearing problems.
Literature provides a growing amount of information on changing patterns in childhood diseases.
The following recommendations for action are formulated: Immediate research on endocrine disrupters in relation to prematurity. Diabetes: avoid Maillard Compounds in liquid baby food and in food in general: promote breastfeeding. Asthma: avoid exposure to smoking, the use of chemical household products, dioxin and dioxin-like chemicals, and avoid air pollution with high levels of particulate matter, especially around conception, during pregnancy and in the first years of life. Autism: more research on incidence and causes. ADHD and learning disabilities: more research on prevalence and causes. Preventions: 1) preconception counselling to avoid potentially harmful substances; 2) controlling and further lowering levels of polychlorinated biphenyls, lead and methyl mercury. Cancer: promote breastfeeding, carry out research into effects of foetal exposure to internal fission-product radionuclides. Obesity: stop smoking in pregnancy, avoid parental obesity, longer night sleep. Hearing problems: lower noise levels in discothèques, promote the day-evening-night level to avoid noise (longer night sleep).
文献中描述了一些儿童疾病或病症与儿童发育阶段(包括产前和产后)外部应激源之间关系的事实和假设。本文总结了主要儿童疾病模式和病因的以下变化,并提出了行动建议。早产。宫内生长受限。睾丸发育不全综合征。I型和II型糖尿病。哮喘、特应性和花粉热。自闭症。注意力缺陷多动障碍(ADHD)。学习障碍。癌症。肥胖症。听力问题。
文献提供了越来越多关于儿童疾病模式变化的信息。
制定了以下行动建议:立即开展关于早产与内分泌干扰物关系的研究。糖尿病:避免婴儿液体食品及一般食品中的美拉德化合物;提倡母乳喂养。哮喘:避免接触吸烟、使用家用化学品、二噁英和二噁英类化学品,避免接触高颗粒物空气污染,尤其是在受孕前后、孕期及生命最初几年。自闭症:对发病率和病因进行更多研究。ADHD和学习障碍:对患病率和病因进行更多研究。预防措施:1)孕前咨询以避免潜在有害物质;2)控制并进一步降低多氯联苯、铅和甲基汞的水平。癌症:提倡母乳喂养,开展胎儿接触内裂变产物放射性核素影响的研究。肥胖症:孕期戒烟,避免父母肥胖,保证更长的夜间睡眠时间。听力问题:降低迪斯科舞厅的噪音水平,提倡采用日-晚-夜模式以避免噪音(保证更长的夜间睡眠时间)。