Ahlstrom Christer, Hult Peter, Rask Peter, Karlsson Jan-Erik, Nylander Eva, Dahlström Ulf, Ask Per
Department of Biomedical Engineering, University Hospital, Linköping University, IMT, SE-581 85, Linköping, Sweden.
Ann Biomed Eng. 2006 Nov;34(11):1666-77. doi: 10.1007/s10439-006-9187-4. Epub 2006 Oct 4.
Heart murmurs are often the first signs of pathological changes of the heart valves, and they are usually found during auscultation in the primary health care. Distinguishing a pathological murmur from a physiological murmur is however difficult, why an "intelligent stethoscope" with decision support abilities would be of great value. Phonocardiographic signals were acquired from 36 patients with aortic valve stenosis, mitral insufficiency or physiological murmurs, and the data were analyzed with the aim to find a suitable feature subset for automatic classification of heart murmurs. Techniques such as Shannon energy, wavelets, fractal dimensions and recurrence quantification analysis were used to extract 207 features. 157 of these features have not previously been used in heart murmur classification. A multi-domain subset consisting of 14, both old and new, features was derived using Pudil's sequential floating forward selection (SFFS) method. This subset was compared with several single domain feature sets. Using neural network classification, the selected multi-domain subset gave the best results; 86% correct classifications compared to 68% for the first runner-up. In conclusion, the derived feature set was superior to the comparative sets, and seems rather robust to noisy data.
心脏杂音通常是心脏瓣膜病理变化的最初迹象,通常在初级卫生保健听诊时被发现。然而,区分病理性杂音和生理性杂音很困难,因此具有决策支持能力的“智能听诊器”将具有很大价值。从36例患有主动脉瓣狭窄、二尖瓣关闭不全或生理性杂音的患者身上采集了心音图信号,并对数据进行分析,目的是找到一个适合自动分类心脏杂音的特征子集。使用了诸如香农能量、小波、分形维数和递归量化分析等技术来提取207个特征。这些特征中有157个以前未用于心脏杂音分类。使用普迪尔的顺序浮动前向选择(SFFS)方法得出了一个由14个新旧特征组成的多域子集。将该子集与几个单域特征集进行了比较。使用神经网络分类,所选的多域子集给出了最佳结果;正确分类率为86%,而第二名的正确分类率为68%。总之,得出的特征集优于比较集,并且似乎对噪声数据相当稳健。