通过在固体载体上高效应用烯烃交叉复分解反应合成3-（芳基）烯基-β-内酰胺

Synthesis of 3-(aryl)alkenyl-beta-lactams by an efficient application of olefin cross-metathesis on solid support.

作者信息

Testero Sebastian A, Mata Ernesto G

机构信息

Instituto de Química Organica de Síntesis. Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario-CONICET, Suipacha 531, S2002LRK Rosario, Argentina.

出版信息

Org Lett. 2006 Oct 12;8(21):4783-6. doi: 10.1021/ol061786u.

DOI:10.1021/ol061786u

PMID:17020302

Abstract

[reaction: see text] An efficient cross-metathesis on solid support for the synthesis of beta-lactam analogues of cholesterol absorption inhibitors is described. The applied strategy allows the introduction of diversity in positions 3 and 4 of the beta-lactam ring with excellent 3,4-trans selectivity and complete E selectivity at the C-3 side chain.

摘要

[反应：见正文] 描述了一种用于合成胆固醇吸收抑制剂的β-内酰胺类似物的在固体载体上的高效交叉复分解反应。所应用的策略能够在β-内酰胺环的3位和4位引入多样性，具有出色的3,4-反式选择性以及在C-3侧链上完全的E选择性。