[偏执型精神分裂症患者中EQ-5D生活质量问卷的判别能力、结构效度及对变化的敏感性]

[Discriminative ability, construct validity and sensitivity to change of the EQ-5D quality of life questionnaire in paranoid schizophrenia].

作者信息

Konnopka Alexander, Günther Oliver H, Angermeyer Matthias C, König Hans-Helmut

机构信息

Stiftungsprofessur für Gesundheitsökonomie, Universität Leipzig, Germany.

出版信息

Psychiatr Prax. 2006 Oct;33(7):330-6. doi: 10.1055/s-2006-940125.

DOI:10.1055/s-2006-940125

PMID:17024582

Abstract

OBJECTIVE

To analyze the discriminative ability, construct validity and sensitivity to change of the EQ-5D in paranoid schizophrenia (ICD-10 F20.0).

METHODS

Data of 408 patients was analyzed in a longitudinal study by comparing EQ-5D with SF-36, CGI-S, PANSS, and GAF.

RESULTS

EQ-5D showed considerable discriminative ability in the patient sample when compared to a representative population sample. If a measure used for comparison and a EQ-5D dimension were theoretically corresponding, the measure's mean score differed significantly between EQ-5D answer levels, with largest effect sizes for SF-36 scales (0.34<|d|<1.76), but rather small values for CGI-S, PANSS and GAF (|d|<0.5). EQ-5D VAS (mean 61.3) and German EQ-5D index (mean 0.84) showed rather moderate correlations with most other scales (0.18<|r|<0.62). ROC-analysis indicated a very low sensitivity to change of EQ VAS and German EQ-5D index (0.50<AUC<0.58).

CONCLUSIONS

Although focusing on physical problems, the EQ-5D seems to have reasonable discriminative ability and construct validity, but very low sensitivity to change.

摘要

目的

分析EQ-5D量表在偏执型精神分裂症（ICD-10 F20.0）中的区分能力、结构效度及对变化的敏感性。

方法

在一项纵向研究中，通过将EQ-5D量表与SF-36、CGI-S、PANSS和GAF量表进行比较，分析了408例患者的数据。

结果

与代表性人群样本相比，EQ-5D量表在患者样本中显示出相当的区分能力。如果用于比较的量表与EQ-5D的某个维度在理论上相对应，那么该量表的平均分在EQ-5D的不同回答水平间存在显著差异，其中SF-36量表的效应量最大（0.34<|d|<1.76），而CGI-S、PANSS和GAF量表的效应量较小（|d|<0.5）。EQ-5D视觉模拟量表（VAS，均值61.3）和德国版EQ-5D指数（均值0.84）与大多数其他量表的相关性中等（0.18<|r|<0.62）。ROC分析表明，EQ VAS和德国版EQ-5D指数对变化的敏感性非常低（0.50<AUC<0.58）。