Halder S L S, Locke G R, Schleck C D, Zinsmeister A R, Talley N J
Department of Gastroenterology, Hope Hospital, University of Manchester, Manchester, UK.
Neurogastroenterol Motil. 2006 Nov;18(11):1001-8. doi: 10.1111/j.1365-2982.2006.00815.x.
The role of alcohol use in irritable bowel syndrome (IBS) and dyspepsia is not well understood. We hypothesised that people with psychological distress who drink no alcohol, or excess alcohol, are at increased risk of having IBS or dyspepsia. Valid gastrointestinal (GI) symptom surveys were mailed to randomly selected cohorts of community residents. Associations between IBS, dyspepsia and abdominal pain and alcohol use were assessed using logistic regression adjusted for a Somatic Symptom Checklist score (SSC). A total of 4390 (80%) responded; of these, 10.5% reported IBS, 2% dyspepsia and 22% abdominal pain. Alcohol consumption >7 drinks week(-1) was associated with a greater odds for dyspepsia (OR 2.3; 95% CI:1.1-5.0) and frequent abdominal pain (OR 1.5; 95% CI: 1.1-2.0) but not IBS. However, significant interactions among gender, alcohol use and SSC scores were detected (P < 0.005). In females with a low SSC score, consuming alcohol > or =7 drinks week(-1) increased the odds of IBS compared to drinking alcohol moderately. Alcohol consumption was associated with dyspepsia and abdominal pain. A relationship with IBS was identified when interactions with somatization and gender were appropriately considered. Whether these associations are due to the effects of alcohol on the gut, or a common central mechanism remains to be determined.
饮酒在肠易激综合征（IBS）和消化不良中所起的作用尚未得到充分了解。我们推测，心理困扰且不饮酒或过量饮酒的人患IBS或消化不良的风险会增加。有效的胃肠道（GI）症状调查问卷被邮寄给随机抽取的社区居民队列。使用针对躯体症状清单评分（SSC）进行调整的逻辑回归分析来评估IBS、消化不良、腹痛与饮酒之间的关联。共有4390人（80%）做出回应；其中，10.5%的人报告患有IBS，2%的人患有消化不良，22%的人有腹痛症状。每周饮酒超过7杯与消化不良（比值比2.3；95%置信区间：1.1 - 5.0）和频繁腹痛（比值比1.5；95%置信区间：1.1 - 2.0）的较高几率相关，但与IBS无关。然而，检测到性别、饮酒与SSC评分之间存在显著交互作用（P < 0.005）。在SSC评分较低的女性中，与适度饮酒相比，每周饮酒≥7杯会增加患IBS的几率。饮酒与消化不良和腹痛相关。在适当考虑与躯体化和性别的交互作用后，确定了与IBS的关系。这些关联是由于酒精对肠道的影响，还是共同的中枢机制，仍有待确定。
