由于胰岛素调节的PI3激酶导致的黑腹果蝇滞育的自然变异。
Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase.
作者信息
Williams Karen D, Busto Macarena, Suster Maximiliano L, So Anthony K-C, Ben-Shahar Yehuda, Leevers Sally J, Sokolowski Marla B
机构信息
Department of Biology, University of Toronto, 3359 Mississauga Road, Mississauga, ON, Canada L5L 1C6.
出版信息
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15911-5. doi: 10.1073/pnas.0604592103. Epub 2006 Oct 16.
Abstract
This study links natural variation in a Drosophila melanogaster overwintering strategy, diapause, to the insulin-regulated phosphatidylinositol 3-kinase (PI3-kinase) gene, Dp110. Variation in diapause, a reproductive arrest, was associated with Dp110 by using Dp110 deletions and genomic rescue fragments in transgenic flies. Deletions of Dp110 increased the proportion of individuals in diapause, whereas expression of Dp110 in the nervous system, but not including the visual system, decreased it. The roles of phosphatidylinositol 3-kinase for both diapause in D. melanogaster and dauer formation in Caenorhabditis elegans suggest a conserved role for this kinase in both reproductive and developmental arrests in response to environmental stresses.
摘要
本研究将黑腹果蝇越冬策略（滞育）的自然变异与胰岛素调节的磷脂酰肌醇3激酶（PI3激酶）基因Dp110联系起来。通过在转基因果蝇中使用Dp110缺失和基因组拯救片段，滞育（一种生殖停滞）的变异与Dp110相关联。Dp110的缺失增加了滞育个体的比例，而Dp110在神经系统（但不包括视觉系统）中的表达则降低了滞育个体的比例。磷脂酰肌醇3激酶在黑腹果蝇滞育和秀丽隐杆线虫 dauer形成中的作用表明，该激酶在应对环境压力时，在生殖和发育停滞中具有保守作用。
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