Fluxional additives: a second generation control in enantioselective catalysis.
作者信息
Sibi Mukund P, Manyem Shankar, Palencia Hector
机构信息
Department of Chemistry and Molecular Biology, North Dakota State University, Fargo, North Dakota 58105, USA.
出版信息
J Am Chem Soc. 2006 Oct 25;128(42):13660-1. doi: 10.1021/ja064472a.
PMID:17044673
Abstract
The concept of "fluxional additives", additives that can adopt enantiomeric conformations depending on the chiral information in the ligand, is demonstrated in enantioselective Diels-Alder and nitrone cycloaddition reactions. The additive design is modular, and diverse structures are accessible in three steps. Chiral Lewis acids from main group and transition metals show enhancements in enantioselectivity in the presence of these additives.
摘要
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