Marsh Elisabeth B, Hillis Argye E
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Prog Brain Res. 2006;157:143-56. doi: 10.1016/S0079-6123(06)57009-8.
Language is predominantly a left hemisphere function, yet patients with extensive damage to known language areas often recover quite well in the days to weeks to even years following focal brain injury. This recovery period can be divided into three overlapping stages: acute, subacute, and chronic, each with different underlying neural mechanisms. Reorganization of structure and function through the expression of neural plasticity plays a crucial role in recovery of language at least during the subacute phase of weeks to months after the occurrence of an injury. In this chapter we review the evidence for reorganization of language function after injury, the role it plays in the recovery of language following brain damage, and how knowledge of the mechanisms of recovery will allow design of more effective methods of rehabilitation.
语言主要是左半球的功能,然而,已知语言区域受到广泛损伤的患者在局灶性脑损伤后的数天、数周甚至数年里往往恢复得相当好。这个恢复期可分为三个重叠阶段:急性期、亚急性期和慢性期,每个阶段都有不同的潜在神经机制。通过神经可塑性的表达进行结构和功能重组,至少在损伤发生后数周至数月的亚急性期,在语言恢复中起着关键作用。在本章中,我们回顾了损伤后语言功能重组的证据、其在脑损伤后语言恢复中所起的作用,以及对恢复机制的了解将如何有助于设计更有效的康复方法。