脑脊液中的抗磷酸丙糖异构酶抗体与神经精神性狼疮相关。
Anti-triosephosphate isomerase antibodies in cerebrospinal fluid are associated with neuropsychiatric lupus.
作者信息
Sasajima Tomomi, Watanabe Hiroshi, Sato Shuzo, Sato Yukio, Ohira Hiromasa
机构信息
Fukushima Medical University, Department of Internal Medicine II, School of Medicine, Fukushima 960-1295, Japan.
出版信息
J Neuroimmunol. 2006 Dec;181(1-2):150-6. doi: 10.1016/j.jneuroim.2006.09.003. Epub 2006 Oct 24.
We detected anti-triosephosphate isomerase antibodies (anti-TPI) in cerebrospinal fluid (CSF) in 5 of 12 neuropsychiatric lupus patients (41.6%) by Western blotting. C3d index was significantly higher in anti-TPI-positive patient (n=5, median 0.446) than in anti-TPI-negative patient (n=7, median 0.098) (p=0.019) CSF samples. TPI was detected from immune complexes (IC) isolated from CSF in 2 of 2 anti-TPI-positive patients tested and was not detected from IC in 5 of 5 anti-TPI-negative patients tested. Our results suggest that anti-TPI form IC in CSF and contribute to the pathogenesis of neuropsychiatric lupus by activating the complement system.
通过蛋白质印迹法，我们在12例神经精神性狼疮患者中的5例（41.6%）脑脊液（CSF）中检测到抗磷酸丙糖异构酶抗体（抗-TPI）。抗-TPI阳性患者（n=5，中位数0.446）的C3d指数显著高于抗-TPI阴性患者（n=7，中位数0.098）（p=0.019）的脑脊液样本。在检测的2例抗-TPI阳性患者中，从CSF分离的免疫复合物（IC）中检测到了TPI，而在检测的5例抗-TPI阴性患者中，IC中未检测到TPI。我们的结果表明，抗-TPI在CSF中形成IC，并通过激活补体系统促进神经精神性狼疮的发病机制。
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