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成人斜视手术的成本效用

The cost utility of strabismus surgery in adults.

作者信息

Beauchamp Cynthia L, Beauchamp George R, Stager David R, Brown Melissa M, Brown Gary C, Felius Joost

机构信息

Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, USA.

出版信息

J AAPOS. 2006 Oct;10(5):394-9. doi: 10.1016/j.jaapos.2006.06.004.

Abstract

PURPOSE

Cost-utility analysis evaluates the cost of medical care in relation to the gain in quality-adjusted life years (QALYs). Our purpose was to develop a cost model for surgical care for adult strabismus, to estimate the mean cost per case, to determine the associated gain in QALYs, and to perform cost-utility analysis.

METHODS

A cost model incorporated surgery, pre- and postoperative care, and a mean of 1.5 procedures per patient. The gain in QALYs was based on the improvement of utility on a scale from 0 (death) to 1 (perfect health). Utility was measured through physician-conducted interviews employing a time tradeoff question (seeking to estimate the portion of life expectancy a patient would be willing to trade for being rid of disease and associated effects). The interviews were conducted before and 5 to 8 weeks after surgery in 35 strabismic patients (age 19-75 years).

RESULTS

The cost model resulted in an estimated total cost of 4,254 dollars per case. A significant improvement of utility was found: 0.96 +/- 0.11 postoperatively versus 0.85 +/- 0.20 preoperatively (p = 0.00008). Based on the mean life expectancy (36.0 years) of these patients, and discounting outcomes and costs by 3% annually, this resulted in a mean value gain of 2.61 QALYs after surgery and a cost-utility for strabismus surgery of 1,632 dollas/QALY.

CONCLUSIONS

In the United States, treatments <50,000 dollars/QALY are generally considered "very cost-effective." Strabismus surgery in adults falls well within this range.

摘要

目的

成本效用分析评估医疗护理成本与质量调整生命年(QALY)增益之间的关系。我们的目的是建立一个成人斜视手术护理的成本模型,估计每例手术的平均成本,确定相关的QALY增益,并进行成本效用分析。

方法

成本模型纳入了手术、术前和术后护理,以及每位患者平均1.5次手术。QALY的增益基于效用从0(死亡)到1(完美健康)的改善。效用通过医生进行的访谈来测量,采用时间权衡问题(旨在估计患者为摆脱疾病及相关影响而愿意牺牲的预期寿命比例)。对35例斜视患者(年龄19 - 75岁)在手术前以及手术后5至8周进行了访谈。

结果

成本模型得出每例手术的估计总成本为4254美元。发现效用有显著改善:术后为0.96±0.11,术前为0.85±0.20(p = 0.00008)。基于这些患者的平均预期寿命(36.0岁),并按每年3%对结果和成本进行贴现,这导致手术后平均QALY增益为2.61,斜视手术的成本效用为1632美元/QALY。

结论

在美国,每QALY成本低于50000美元的治疗通常被认为“非常具有成本效益”。成人斜视手术完全在这个范围内。

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