[与血液系统恶性肿瘤相关的SDF-1/CXCR4轴的研究进展：综述]

[Research advance on SDF-1/CXCR4 axis associated with hematological malignancies: review].

作者信息

Dai Yong-Yuan, Chen Bao-An

机构信息

Depatment of Hematology, Clinical Medical College, Southeast University, Nanjing 210009, China.

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Oct;14(5):1056-60.

PMID:17096920

Abstract

The stromal cell-derived factor 1 (SDF-1) interacts with its receptor CXCR4 to transduction signals, playing important roles in most physiological and pathological processes. It is reported that CXCR4 is highly expressed in many kinds of hematological malignancies and closely related to the prognosis, drug resistance and relapse of diseases. The growth of tumor cells can be inhibited by the anti-SDF-1 antibody or anti- CXCR4 antibody, supporting a new way for the therapy against hematological malignancies. Their expression in relation with prognosis and drug resistance of hematological malignancies are summarized in this review.

摘要

基质细胞衍生因子1（SDF-1）与其受体CXCR4相互作用以传导信号，在大多数生理和病理过程中发挥重要作用。据报道，CXCR4在多种血液系统恶性肿瘤中高表达，且与疾病的预后、耐药性和复发密切相关。抗SDF-1抗体或抗CXCR4抗体可抑制肿瘤细胞的生长，为血液系统恶性肿瘤的治疗提供了新途径。本文综述了它们在血液系统恶性肿瘤预后和耐药性方面的表达情况。